API wholesale Celecoxib powder 99.8% 169590-42-5
Celecoxib powder belongs to the class NSAID (non-steroidal anti-inflammatory drug) family. It's available under the trade name Celebrex.
Celebrex powder is used to treat osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis (AS), acute pain, and primary dysmenorrhoea (painful menstruation).
This substance acts by selectively inhibiting the COX-2 pathway - which is one of the primary enzymes responsible for producing inflammatory messengers. This effect reduces various mediators of pain and inflammation.
Celecoxib is available by prescription-only as per the FDA.
| Xi'an sheerherb biological technology Co., Ltd |
| Name |
Celecoxib |
| CAS Number |
169590-42-5 |
| Molecular Formula |
C17H14F3N3O2S |
| Molecular Weight |
381.372 |
| Assay |
99% |
| Country of Origin |
Xi'an,China |
| Shelf Life |
2 Years |
| Specification |
Celecoxib 99% |
Celecoxib powder is used to relieve symptoms caused by osteoarthritis (arthritis caused by destruction of the lining of joints), rheumatoid arthritis (arthritis caused by swelling of the lining of joints), and ankylosing spondylitis (arthritis) Pain, tenderness, swelling, and stiffness. mainly affects the spine). Celecoxib is also used to treat painful menstrual periods and pain from other causes. It is also used with surgery and other treatments to reduce polyps (abnormal growths) in the colon (large intestine) and rectum in patients with familial adenomatous polyposis (a condition in which hundreds or thousands of polyps form in the colon and cancer) number may develop). Celecoxib belongs to a class of non-steroidal anti-inflammatory drugs called COX-2 inhibitors. It works by stopping the body from producing substances that cause pain and inflammation.
| Quality level |
100 |
| Determination |
≥98% (HPLC) |
| Form |
powder |
| Color |
white to beige |
| Solubility |
DMSO: 2 mg/mL, clear |
| SMILES string |
Cc1ccc(cc1)-c2cc(nn2-c3ccc(cc3)S(N)(=O)=O)C(F)(F)F |
| InChI |
1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9- 7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) |
| InChI key |
RZEKVGVHFLEQIL-UHFFFAOYSA-N |
How Does Celecoxib powder Work?
Phospholipids present in the membranes of the human body are converted to compounds called arachidonic acids. These arachidonic acids are metabolized via two pathways, COX-1, and COX-2 pathways, producing different prostaglandins and thromboxanes. These different prostaglandins are responsible for mediating pain and inflammation through various metabolites.
Celecoxib is a potent, selective cyclooxygenase-2 (COX-2) inhibitor and exerts minimal action on the cyclooxygenase-1 (COX-1) pathway. The COX-2 pathway, when inhibited, prevents the formation of different prostaglandins responsible for pain and inflammation.
The COX-1 pathway is responsible for prostaglandin-mediated maintenance of gut epithelium and thromboxane-mediated promoting platelet aggregation. Since celecoxib relatively spares the COX-1 pathway, gastrointestinal side effects are rare, while the imbalance between prothrombotic and antithrombotic mediators leads to the risk of thrombo-vascular events.
Celecoxib is readily absorbed when taken orally and binds to plasma proteins. Its half-life is approximately 11 hours, so it is given once or twice daily for optimal therapeutic benefits.
Simultaneous use of enhances the effect on pain and inflammation while also increasing the risk of side effects. Concurrent use might lead to headaches, dyspepsia, gastrointestinal bleed, and renal toxicities.
Xi'an Sheerherb Biological Technology Co., Ltd
We have our own R&D center, quality control center, marketing center, international trade center, etc., and realize the integration of the entire industry chain from global raw material selection, digital integration of finished product processing, automatic filling, international standardized quality inspection to pharmaceutical level , Packaging material production base. We have passed HACCP, ISO22000, FDA and other certifications.
Our company participated in the China Import and Export Commodities Fair. Through these exhibitions, we have a more intuitive understanding of the current world market demand, and then continue to improve our formulations, technology, etc. To manufacture high-quality and popular products. In addition, our products have won the attention of customers all over the world with their good taste and quality. Our company has achieved fruitful results in these exhibitions, and conducted in-depth exchanges with buyers from many countries, and reached relevant cooperation intentions.
As one of the world's largest contract manufacturers, Xi'an Sheerherb Biological Technology Co., Ltd sincerely welcomes you to join us to achieve more cooperation in the future.
Q1: Can i get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union
or Paypal or Escrow(Alibaba).
Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the
samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What's your MOQ?
A:Our MOQ is 1kg or 10g(Different products have different MOQs). But usually we accept less quantity such as 10g on the condition that sample charge is 100% paid.
Q5: How about delivery leadtime?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6:Is there a discount?
A:Different quantity has different discount.
Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8: How to contact us ?
A:You can chat with us by Trademanager,MSN&Skype Online. You can choose your interested products and send inquiry to us. You can dial our telephone directly, you will get our reply. Send Email to us.
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